EVALUATION OF TOXICITY, LOCAL BIOCOMPATIBILITY, BIODEGRADATION, AND SYSTEMIC METABOLISM OF CELLULOSE/ALGINATE/STRONTIUM APATITE MEMBRANES IMPLANTED SUBCUTANEOUSLY IN MICE

Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice

ABSTRACT Purpose: To evaluate membranes originating from pure or oxidized bacterial cellulose (BC)/alginate/strontium apatite hydrogels regarding toxicity, biocompatibility, biodegradation and metabolism.Methods: The toxicity was measured by incubating the materials with Artemia salina for 24 h, and mortality and the 50% lethal concentration were d

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AI vs humans in the AUT: Simulations to LLMs

This paper reviews studies of proposed creative machines applied to a prototypical creative task, i.e., the Alternative Uses Task (AUT).Although one system (OROC) did simulate some aspects of human strategies for the AUT, most recent attempts have not been simulation-oriented, but rather have used Large Language Model (LLM) systems such as GPT-3 wh

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Advantages of the zebrafish (Danio rerio) model in solving contemporary problems of neurotoxicity, teratotoxicity and genotoxicity of xenobiotics

The zebrafish (Danio rerio), a small fish belonging to the Cyprinidae family, is one of the most popular animal models used in laboratory studies, including toxicology.It has many beneficial features, such as transparent body structure, easy and economical breeding, a large number of offspring and a short life cycle.In addition, the genome of the z

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